Selected Research

Disclaimer:

This research summary is provided for educational and informational purposes only. It reflects emerging scientific literature and should not be interpreted as proof of specific medical outcomes, disease treatment, or guaranteed results. Responses to hydrogen water vary by individual, and people may or may not experience the effects described in published research.

This information is not intended as medical advice, diagnosis, or treatment.

Hydrogen Water, Mitochondrial Function, Cellular Health, Energy and Fatigue

Selected Reference List

1. Aoki K, Nakao A, Adachi T, et al. Effects of drinking hydrogen-rich water on muscle

fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012;2:12.

DOI: 10.1186/2045-9912-2-12

Link: https://pubmed.ncbi.nlm.nih.gov/22520831/

2. Botek M, Krejčí J, McKune A, et al. Hydrogen Rich Water Improved Ventilatory,

Perceptual and Lactate Responses to Exercise. Int J Sports Med. 2019;40(14):879-885.

DOI: 10.1055/a-0991-0268

Link: https://pubmed.ncbi.nlm.nih.gov/31574544/

3. Botek M, Krejčí J, McKune AJ, et al. Hydrogen-Rich Water Supplementation and Up-

Hill Running Performance: Effect of Athlete Performance Level. Int J Sports Physiol

Perform. 2020;15(8):1193-1196.

DOI: 10.1123/ijspp.2019-0507

Link: https://pubmed.ncbi.nlm.nih.gov/32045879/

4. Gvozdjáková A, Kucharská J, Kura B, et al. A new insight into the molecular

hydrogen effect on coenzyme Q and mitochondrial function of rats. Can J Physiol

Pharmacol. 2020;98(1):29-34.

DOI: 10.1139/cjpp-2019-0281

Link: https://pubmed.ncbi.nlm.nih.gov/31536712/

5. Hori A, Sobue S, Kurokawa R, et al. Two-week continuous supplementation of

hydrogen-rich water increases peak oxygen uptake during an incremental cycling

exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study.

Med Gas Res. 2020;10(4):163-169.E

DOI: 10.4103/2045-9912.304223

Link: https://pubmed.ncbi.nlm.nih.gov/33380582/

6. Li Y, Liu Y, Wang W, et al. Can molecular hydrogen supplementation reduce exercise-

induced oxidative stress in healthy adults? A systematic review and meta-analysis. Front

Nutr. 2024;11:1328705.

DOI: 10.3389/fnut.2024.1328705

Link: https://pubmed.ncbi.nlm.nih.gov/38590828/

7. Mikami T, Tano K, Lee H, et al. Drinking hydrogen water enhances endurance and

relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Can

J Physiol Pharmacol. 2019;97(9):857-862.

DOI: 10.1139/cjpp-2019-0059

Link: https://pubmed.ncbi.nlm.nih.gov/31251888/

8. Murakami Y, Ito M, Ohsawa I. Molecular hydrogen protects against oxidative stress-

induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. PLoS

One. 2017;12(5):e0176992.

DOI: 10.1371/journal.pone.0176992

Link: https://pubmed.ncbi.nlm.nih.gov/28467497/

9. Sim M, Kim CS, Shon WJ, et al. Hydrogen-rich water reduces inflammatory responses

and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-

blind, controlled trial. Sci Rep. 2020;10(1):12130.

DOI: 10.1038/s41598-020-68930-2

Link: https://pubmed.ncbi.nlm.nih.gov/32699287/

10. Tan Y, Xie Y, Dong G, et al. The Effect of 14-Day Consumption of Hydrogen-Rich

Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A

Pilot, Single-Blind, and Randomized, Controlled Trial. Nutrients. 2024;16(10):1529.

DOI: 10.3390/nu16101529

Link: https://pubmed.ncbi.nlm.nih.gov/38794767/

11. Timón R, Olcina G, Camacho-Cardeñosa M, et al. Effects of 7-day intake of

hydrogen-rich water on physical performance of trained and untrained subjects. Biol

Sport. 2021;38(2):269-275.

DOI: 10.5114/biolsport.2020.98625

Link: https://pubmed.ncbi.nlm.nih.gov/34079172/

12. Zhang X, Xie F, Ma S, et al. Mitochondria: one of the vital hubs for molecular

hydrogen’s biological functions. Front Cell Dev Biol. 2023;11:1283820.

DOI: 10.3389/fcell.2023.1283820

Link: https://pubmed.ncbi.nlm.nih.gov/38020926/

13. Zhou K, Liu Y, Wang W, et al. Can molecular hydrogen supplementation enhance

physical performance in healthy adults? A systematic review and meta-analysis. Front

Nutr. 2024;11:1387657.

DOI: 10.3389/fnut.2024.1387657

Link: https://pubmed.ncbi.nlm.nih.gov/38903627/

14. Zhou K, Liu Y, Wang W, et al. Effects of molecular hydrogen supplementation on

fatigue and aerobic capacity in healthy adults: a systematic review and meta-analysis.

Front Nutr. 2023;10:1094767.

DOI: 10.3389/fnut.2023.1094767

Link: https://pubmed.ncbi.nlm.nih.gov/36819697/

Hydrogen Water, Elevation, Altitude, and Hypoxia

Selected Reference List

1. Chen M, Zhang J, Chen Y, et al. Hydrogen protects lung from hypoxia/re-oxygenation

injury by reducing hydroxyl radical production and inhibiting inflammatory responses.

Sci Rep. 2018.

DOI: 10.1038/s41598-018-26335-2

Link: https://pubmed.ncbi.nlm.nih.gov/29789753/

2. Shi QH, Shi JD, Zhang Y, et al. Hydrogen Therapy Reduces Oxidative Stress-

associated Risks Following Acute and Chronic Exposure to High-altitude Environment.

Biomed Environ Sci. 2015.

DOI: 10.3967/bes2015.034

Link: https://pubmed.ncbi.nlm.nih.gov/25800452/

3. Tang X, Liang L, Hu L, et al. Electrolysis of water is an effective source of oxygen at

high altitude. J Transl Med. 2022.

DOI: 10.1186/s12967-022-03443-2

Link: https://pubmed.ncbi.nlm.nih.gov/35619109/

4. Zhang F, Zhong Y, Li Q, et al. Does Hydrogen-Rich Water Reduce Oxidative Stress in

Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.

High Alt Med Biol. 2025.

DOI: 10.1177/15578682251401137

Link: https://pubmed.ncbi.nlm.nih.gov/41371770/

5. Zhang Q, Zhang F, Zhong Y, et al. Hydrogen-rich water supplementation attenuates

oxidative stress and inflammation in chronic high-altitude disease patients: A double-

blind randomized placebo-controlled study. Food Res Int. 2025.

DOI: 10.1016/j.foodres.2025.117118

Link: https://pubmed.ncbi.nlm.nih.gov/40922182/

Hydrogen Water, Mental Clarity, and Focus

Selected Reference List

1. Mizuno K, et al. Hydrogen-rich water for improvements of mood, anxiety, and

autonomic nerve function in daily life. Med Gas Res. 2018.

DOI: Not listed in your source

Link: https://pubmed.ncbi.nlm.nih.gov/29497485/

2. Nishimaki K, et al. Effects of Molecular Hydrogen Assessed by an Animal Model and a

Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res. 2018.

DOI: 10.2174/1567205014666171107115738

Link: https://pubmed.ncbi.nlm.nih.gov/29110615/

3. Todorovic N, et al. Hydrogen-rich water and caffeine for alertness and brain metabolism

in sleep-deprived habitual coffee drinkers. Food Sci Nutr. 2021.

DOI: 10.1002/fsn3.2480

Link: https://pubmed.ncbi.nlm.nih.gov/34532023/

4. Zanini D, et al. The effects of 6-month hydrogen-rich water intake on biomarkers of

aging in healthy older adults: A randomized controlled pilot trial. Exp Gerontol. 2021.

DOI: 10.1016/j.exger.2021.111552

Link: https://pubmed.ncbi.nlm.nih.gov/34601077/

Hydrogen Water and Antioxidant Support

Selected Reference List

1. Kang KM, Kang YN, Choi IB, et al. Effects of drinking hydrogen-rich water on the

quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011.

DOI: Not listed in your source

Link: https://pubmed.ncbi.nlm.nih.gov/22146004/

2. Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on

antioxidant status of subjects with potential metabolic syndrome—an open label pilot

study. J Clin Biochem Nutr. 2010.

DOI: 10.3164/jcbn.09-100

Link: https://pubmed.ncbi.nlm.nih.gov/20216947/

3. Ohta S. Molecular hydrogen as a novel antioxidant: overview of the advantages of

hydrogen for medical applications. Methods Enzymol. 2015.

DOI: Not listed in your source

Link: https://pubmed.ncbi.nlm.nih.gov/25747486/

4. Sim M, Kim CS, Shon WJ, et al. Hydrogen-rich water reduces inflammatory responses

and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-

blind, controlled trial. Sci Rep. 2020.

DOI: 10.1038/s41598-020-68930-2

Link: https://pubmed.ncbi.nlm.nih.gov/32699287/

Hydrogen Water, Hydration, and Recovery

Selected Reference List

1. Aoki K, Nakao A, Adachi T, et al. Pilot study: Effects of drinking hydrogen-rich water

on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012.

DOI: 10.1186/2045-9912-2-12

Link: https://pubmed.ncbi.nlm.nih.gov/22520831/

2. Botek M, Krejčí J, McKune A, et al. Hydrogen Rich Water Consumption Positively

Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle

Soreness After Resistance Training. J Strength Cond Res. 2022.

DOI: 10.1519/JSC.0000000000003979

Link: https://pubmed.ncbi.nlm.nih.gov/33555824/

3. Dong G, Fu J, Bao D, Zhou J. Short-Term Consumption of Hydrogen-Rich Water

Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes:

Evidence from a Pilot Study. Int J Environ Res Public Health. 2022.

DOI: 10.3390/ijerph19095413

Link: https://pubmed.ncbi.nlm.nih.gov/35564808/

4. Sládečková B, Botek M, Krejčí J, et al. Hydrogen-rich water supplementation promotes

muscle recovery after two strenuous training sessions performed on the same day in elite

fin swimmers: randomized, double-blind, placebo-controlled, crossover trial. Front

Physiol. 2024.

DOI: 10.3389/fphys.2024.1321160

Link: https://pubmed.ncbi.nlm.nih.gov/38681143/

5. Zhou Q, Li H, Zhang Y, et al. Hydrogen-Rich Water to Enhance Exercise Performance:

A Review of Effects and Mechanisms. Metabolites. 2024.

DOI: 10.3390/metabo14100537

Link: https://pubmed.ncbi.nlm.nih.gov/39452918/

Hydrogen Water and Oxidative Stress

Selected Reference List

1. Dobashi S, Kawaguchi Y, Wada Y, et al. Hydrogen-rich water suppresses the reduction

in blood total antioxidant capacity induced by 3 repeated days of severe exercise in

physically active males. Med Gas Res. 2020.

DOI: Not listed in your source

Link: https://pubmed.ncbi.nlm.nih.gov/33437313/

2. Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: a review of clinical

and experimental studies. J Int Med Res. 2010.

DOI: 10.1177/147323001003800504

Link: https://pubmed.ncbi.nlm.nih.gov/21226992/

3. LeBaron TW, Singh RB, Fatima G, et al. The Effects of 24-Week, High-Concentration

Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation

Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled

Trial. Diabetes Metab Syndr Obes. 2020.

DOI: 10.2147/DMSO.S240122

Link: https://pubmed.ncbi.nlm.nih.gov/32273740/

4. Li Y, Bing R, Liu M, et al. Can molecular hydrogen supplementation reduce exercise-

induced oxidative stress in healthy adults? A systematic review and meta-analysis. Front

Nutr. 2024.

DOI: 10.3389/fnut.2024.1328705

Link: https://pubmed.ncbi.nlm.nih.gov/38590828/

5. Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on

antioxidant status of subjects with potential metabolic syndrome—an open label pilot

study. J Clin Biochem Nutr. 2010.

DOI: 10.3164/jcbn.09-100

Link: https://pubmed.ncbi.nlm.nih.gov/20216947/

6. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant

by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007.

DOI: 10.1038/nm1577

Link: https://pubmed.ncbi.nlm.nih.gov/17486089/

7. Sim M, Kim CS, Shon WJ, et al. Hydrogen-rich water reduces inflammatory responses

and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-

blind, controlled trial. Sci Rep. 2020.

DOI: 10.1038/s41598-020-68930-2

Link: https://pubmed.ncbi.nlm.nih.gov/32699287/

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